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LouieSlocombe/README.md

Hi, I'm Louie Slocombe 👋

Postdoctoral researcher & lab manager, University of Birmingham — theoretical physics and chemistry applied to living systems
Personal website Google Scholar ORCiD

🧬 About Me

I'm a postdoctoral researcher and lab manager at the University of Birmingham. I am interested in understanding how life utilises chemistry to function. I have a background in theoretical physics and chemistry, and I apply it to biological systems.

🧠 Research Focus

  • Nuclear quantum effects in biochemical reactions
  • DNA mutations
  • Protein folding
  • Assembly theory and molecular complexity
  • Life detection

📄 Selected Publications

Year Title Venue
2026 CBR-db: A Cheminformatic Database for Biochemical Reaction Analysis ACS Synthetic Biology
2025 Understanding water behaviour on 2D material interfaces through single-molecule motion on h-BN and graphene Nature Communications
2025 The Emergence of Chirality from Metabolism arXiv (preprint)
2024 Measuring Molecular Complexity ACS Central Science
2023 Multiscale simulations reveal the role of PcrA helicase in protecting against spontaneous point mutations in DNA Scientific Reports
2022 An open quantum systems approach to proton tunnelling in DNA Communications Physics
2021 Quantum biology: An update and perspective Quantum Reports

Full list on Google Scholar

🛠️ Featured Code

Project Description
assemblytheorytools Centralised Python toolkit for assembly theory calculations, with C++/Rust backends and RDKit/NetworkX support.
assemblycfg String assembly index calculator using the smallest-grammar Re-Pair algorithm.
CBRdb Curated biochemical database integrating and refining KEGG and ATLAS data for reaction analysis.
HEOM.jl Hierarchical Equations of Motion in Julia for simulating open quantum systems.

The ELIFE-ASU repositories are from my time with the Emergence of Life group at Arizona State University, and remain actively maintained.

Assembly theory quantifies the complexity of an object by the minimal number of steps needed to build it from fundamental building blocks — treating objects not as simple particles but as entities defined by their possible formation histories, and giving a measure of how much selection was required to produce them.

🤝 Let's Connect

Popular repositories Loading

  1. CenteredDifferences CenteredDifferences Public

    Minimal centered differences package

    Julia 3

  2. HEOM.jl HEOM.jl Public

    Hierarchical Equations of Motion in Julia

    Julia 3 2

  3. Effect-of-Helicase-Separation-on-GC-Tautomerism Effect-of-Helicase-Separation-on-GC-Tautomerism Public

    Effect of Helicase Cleavage on Guanine - Cytosine Tautomerism

    Python 2

  4. MethylatedProtonTransfer MethylatedProtonTransfer Public

    This is the repo for the paper which investigates who methylation and DNA strand separation change the proton transfer dynamics

    Python 2

  5. HPC-Examples HPC-Examples Public

    Example input files for Eureka HPC

    Python 1

  6. LS-ASE-Utils LS-ASE-Utils Public

    Some useful functions for ASE

    Python 1