Hi,
In LoFreq's introduction, it states that "It automatically adapts to changes in coverage and sequencing quality and can therefore be applied to a variety of data-sets e.g. viral/quasispecies, bacterial, metagenomics or somatic data". Are there specific steps within LoFreq designed to counteract the influence of varying coverage? I haven't found any corresponding explanation in the LoFreq article regarding how it automatically adapts to changes in coverage. How does LoFreq automatically adapt to changes in coverage?
Thanks
Hi,
In LoFreq's introduction, it states that "It automatically adapts to changes in coverage and sequencing quality and can therefore be applied to a variety of data-sets e.g. viral/quasispecies, bacterial, metagenomics or somatic data". Are there specific steps within LoFreq designed to counteract the influence of varying coverage? I haven't found any corresponding explanation in the LoFreq article regarding how it automatically adapts to changes in coverage. How does LoFreq automatically adapt to changes in coverage?
Thanks