diff --git a/src/components/ContextualMenu/ContextualMenu.test.tsx b/src/components/ContextualMenu/ContextualMenu.test.tsx
index 5fd5122f7..4a7f5b2a0 100644
--- a/src/components/ContextualMenu/ContextualMenu.test.tsx
+++ b/src/components/ContextualMenu/ContextualMenu.test.tsx
@@ -371,6 +371,65 @@ describe("ContextualMenu ", () => {
       expect(screen.getByTestId("item-0")).not.toHaveFocus();
     });
 
+    it("routes Tab into the menu when it was opened by a mouse", async () => {
+      // A focusable element rendered after the menu: without routing, Tab
+      // walks the page instead of entering the open menu.
+      const links = [0, 1].map((i) => ({
+        "data-testid": `item-${i}`,
+        children: `Item ${i}`,
+      }));
+      const user = userEvent.setup({ advanceTimers: jest.advanceTimersByTime });
+      render(
+        <>
+          <ContextualMenu
+            links={links}
+            dropdownProps={{ "data-testid": "dropdown" }}
+            toggleLabel={<span>toggle</span>}
+          />
+          <button data-testid="after" type="button">
+            after
+          </button>
+        </>,
+      );
+      const toggle = screen.getByRole("button", { name: /toggle/i });
+
+      await user.click(toggle);
+      jest.runOnlyPendingTimers();
+
+      expect(screen.getByTestId("item-0")).not.toHaveFocus();
+
+      await user.tab();
+      expect(screen.getByTestId("item-0")).toHaveFocus();
+      expect(screen.getByTestId("after")).not.toHaveFocus();
+    });
+
+    it("leaves Tab alone when focus is not on the toggle", async () => {
+      const links = [0, 1].map((i) => ({
+        "data-testid": `item-${i}`,
+        children: `Item ${i}`,
+      }));
+      const user = userEvent.setup({ advanceTimers: jest.advanceTimersByTime });
+      render(
+        <>
+          <button data-testid="outside" type="button">
+            outside
+          </button>
+          <ContextualMenu
+            links={links}
+            dropdownProps={{ "data-testid": "dropdown" }}
+            toggleLabel={<span>toggle</span>}
+          />
+        </>,
+      );
+      await user.click(screen.getByRole("button", { name: /toggle/i }));
+      jest.runOnlyPendingTimers();
+
+      // Move focus without clicking, so the menu does not close.
+      screen.getByTestId("outside").focus();
+      await user.tab();
+      expect(screen.getByTestId("item-0")).not.toHaveFocus();
+    });
+
     it("cleans up focus event listeners when unmounted", async () => {
       const { user, toggle, unmount } = setup();
 
diff --git a/src/components/ContextualMenu/ContextualMenu.tsx b/src/components/ContextualMenu/ContextualMenu.tsx
index 22b08de21..70eac52da 100644
--- a/src/components/ContextualMenu/ContextualMenu.tsx
+++ b/src/components/ContextualMenu/ContextualMenu.tsx
@@ -307,7 +307,7 @@ const ContextualMenu = <L,>({
   });
 
   /**
-   * Trap focus within the dropdown
+   * Trap focus within the dropdown and route keyboard focus into it.
    */
   useEffect(() => {
     const handleKeyDown = (e: KeyboardEvent) => {
@@ -325,13 +325,25 @@ const ContextualMenu = <L,>({
         // Shift+Tab on the first item: wrap back to the last focusable item
         e.preventDefault();
         last.focus();
+      } else if (
+        !e.shiftKey &&
+        active ===
+          wrapper.current?.querySelector<HTMLElement>(
+            ".p-contextual-menu__toggle",
+          )
+      ) {
+        // The menu is open but focus is still on the toggle, e.g. the menu
+        // was opened with the mouse: Tab must enter the menu instead of
+        // walking the rest of the page.
+        e.preventDefault();
+        first.focus();
       }
     };
-    const dropdown = getDropdown();
-    if (!dropdown) return undefined;
-    dropdown.addEventListener("keydown", handleKeyDown);
+    // The toggle lives outside the dropdown element, so the listener is
+    // document level to catch both the wrap cases and the toggle case.
+    document.addEventListener("keydown", handleKeyDown);
     return () => {
-      dropdown.removeEventListener("keydown", handleKeyDown);
+      document.removeEventListener("keydown", handleKeyDown);
     };
   }, [getDropdown, getFocusableDropdownItems, isOpen]);